Diclofenacum

Medicine

Related diseases

Nonsteroidal anti-inflammatory drug (NSAID) that inhibits inflammation and pain.

Pain and inflammation due to rheumatic diseases (including juvenile rheumatoid arthritis) or other musculoskeletal system damage
Urinary tract stones
Gout attack
Postoperative pain

Increased sensitivity to the active substance or any excipient
Current or history of peptic ulcer
Current or history of gastrointestinal bleeding related to NSAIDs
Asthma, acute rhinitis, nasal polyps, angioedema, urticaria, or other allergic reactions caused by NSAIDs or acetylsalicylic acid
Severe heart failure
Severe kidney failure
Acute porphyria
Combination with other NSAIDs
Intravenous use: history of hemorrhagic diathesis, diagnosed or suspected hemorrhagic cerebrovascular disorder, high-risk bleeding surgery, bronchial asthma, moderate to severe heart failure (serum creatinine level > 160 micromoles/l), dehydration, hypovolemia, use with anticoagulants
Newborns should not receive preparations containing benzyl alcohol

For Adults:

Orally (after a meal): 50-150 mg per day in 2-3 doses. Optimal daily dose is 100 mg.
Injection (deep into the gluteal muscle):
- Acute or postoperative pain: 75 mg once (if needed, twice) daily for no longer than 2 days.
- Urinary tract stones: initially 75 mg; if needed, another 75 mg after 30 min.
Intravenously (only in a hospital):
- Initially 75 mg; if needed, another 75 mg after 4-6 hours. Do not exceed 150 mg per day for no longer than 2 days.
- For postoperative pain prophylaxis: 25-50 mg every 15-60 min after surgery, then 5 mg/hour. Do not exceed 150 mg per day for no longer than 2 days.
Per rectum: 75-150 mg per day in several doses.

For Children:

Per rectum (suitable for 12.5 mg and 25 mg suppositories):
- Juvenile rheumatoid arthritis: 6-12 years old – 1-2 mg/kg (but not more than 150 mg) per day in several doses for no longer than 4 days.

Most common: gastrointestinal disturbances (discomfort in the abdomen, nausea, diarrhea); hypersensitivity reactions (rash, angioedema, bronchospasm, increased sensitivity to light); headache, dizziness, vertigo; nervousness, depression, drowsiness, insomnia; impaired hearing (usually ringing in the ears); hematuria; rectal irritation (with suppositories); injection site reactions.
Others: gastrointestinal bleeding, peptic ulcer, colitis, Crohn’s disease; hematological disorders; fluid retention (may result in congestive heart failure), hypertension; necrosis of renal papillae, interstitial fibrosis, kidney damage (especially if the kidneys are affected); liver damage; alveolitis, pulmonary eosinophilia; pancreatitis; altered vision; Stevens-Johnson syndrome, toxic epidermal necrolysis; aseptic meningitis (especially in patients with connective tissue diseases).

Not recommended in the first 6 months, prohibited in the last 3 months.
Regular use in the third trimester can lead to fetal arterial duct closure, causing persistent pulmonary hypertension in the newborn. Labor may be delayed and prolonged.

Use with caution in patients with mild or moderate heart failure, mild or moderate kidney failure, allergic diseases, bronchial asthma, impaired blood clotting, connective tissue disease, and gastrointestinal bleeding.
Caution is advised for the elderly and in concomitant use with acetylsalicylic acid.
Monitor kidney function in the presence of heart failure, kidney failure, or heart failure.
Administer the lowest effective dose for the shortest duration possible. Periodically reassess the need for long-term treatment.
Prolonged NSAID use may reduce female fertility, but this effect reverses upon discontinuation.
In the event of gastrointestinal damage, discontinue use unless the patient has severe rheumatic diseases and cannot tolerate pain and discomfort.