Sezary cell
Laboratory test
Norma
Unchanged
Blood
Blood smear
Sezary cell – one of the forms of lymphocytic cells. It can be seen in the blood, usually entering it from tumor nodes in the skin. However, in cases of mycosis fungoides (Sezary syndrome), lymphocytes with characteristic appearance can enter the blood. They have little cytoplasm, can be indented or have a folded nucleus. Unlike typical chronic lymphocytic leukemia, these lymphocytes are rarely abundant in blood smears. Flow cytometry helps to further assess the monoclonal nature of Sezary cells. Immunophenotype: CD2+, CD4+, CD3+, CD5+, (CD7+), (CD8+).
Source | Handbook of Basic Laboratory Tests | Doctor of Medical Sciences Gintaras Zaleskis