VHL protein
Term
Von Hippel-Landau protein consists of 213 amino acids. VHL binds with Cul-2 and elongins B and C, the complex translocates to the nucleus. By sequestering elongins B and C, it halts the formation of the transcription factor (composed of elongins A, B, and C). However, its true function may be the ubiquitination-mediated degradation of other nuclear proteins. Numerous mutations in the VHL gene are associated with sporadic and hereditary renal carcinoma.
Source | Glossary of Most Commonly Used Biomedical Terms and Concepts | Lithuanian University of Health Sciences | Academician Professor Antanas Praškevičius, Professor Laima Ivanovienė