Anti-TG

Norm
0–51× 103 U/l

Synonyms: antithyroglobulin antibodies, Anti-TG, thyroglobulin antibodies, antithyroglobulin.
Serum
Red cap

This indicator is used to diagnose autoimmune thyroid disorders. Sometimes autoimmune thyroid disorders manifest together with signs of thyroid hypofunction, clear laboratory changes: increased TSH and decreased FT4 in the blood. However, anti-TG can also appear much earlier – when there are no signs of thyroid hypofunction yet. Degenerative thyroid disorders with signs of hypothyroidism indicate that there were likely episodes of exacerbation of the autoimmune process earlier. They are often diagnosed late when hypothyroidism is detected. This indicator should be determined together with anti-TPO. Other diseases (non-thyroid autoimmune diseases) can also cause an increase in anti-TG. However, other autoimmune diseases rarely cause thyroid hypofunction, recognized by TSH and FT4 indicators. Some pathologies unrelated to the thyroid that can cause an increase in anti-TG concentration in serum should be mentioned: Sjögren’s syndrome, lupus, rheumatoid arthritis, vitamin B12 deficiency anemia, autoimmune hemolytic anemia. Hemagglutination and <a href=”https://www.ligos.lt/lt/terminai/ca2+/362″>CA2 immunofluorescence are outdated, inaccurate methods for detecting anti-TG.

Source | Handbook of Basic Laboratory Tests | Doctor of Medical Sciences Gintaras Zaleskis